The town of Coreno Ausonio grew up along a hillside road that was an internal connection to the not very fertile Aurunci Mountains, the geology of the mountains being that from which marble is extracted.
The area was under the control of the Abbey of Monte Cassino who gave it to the Princes of Capua.
Until the sixteenth century it consisted of a set of houses, or hamlets belonging to the municipality of Fratte (Ausonia today) governed by many different families. In 1806 it joined the Bourbon Kingdom.
The name dates back to the Greek words Kora oinou, wine country, and in fact wine was the only notable product of ancient Coreno and it was exported to Naples.
During the Second World War bombings have compromised much of the town.