The convent was built near an ancient Roman villa where Christians gathered to listen to the words of Pope Sylvester I. It seems that St. Francis, in his pilgrimage to Rome, chose this place as a place of prayer.
It was founded in the early 1600s by the order of the Discalced (without shoes) Carmelite beggars, thanks to Clement VIII Aldobrandini, on a former convent that belonged to the Franciscans until 1400.
The church was rebuilt in 1660, while the stone façade is of 1854. Inside the monastery houses numerous paintings, a rich collection of pictures and donations from devotees.