Paganico Sabino is located at 720 metres above the Lake of Turano. Its name comes from the Latin Paganicum, name by which in the Middle Ages were called the villages, heirs of the Roman settlements. In particular, some scholars argue that Paganico may have been developed on the site of Falacrine, birthplace of Vespasian.
The present village has the typical appearance of a medieval castrum, which is formed around a fortified place on a hill, and is first mentioned in 852 in the records of the Abbey of Farfa.
After Farfa, it became part of the kingdom of Naples and in the fourteenth century passed under the dominion of Collalto barons, to whom it was linked for a long time.