The medieval village was founded along the Garigliano river around a church dedicated to Sant’Andrea (St. Andrew), built by the abbey of Montecassino.
The church was destroyed by the Saracens in 846 and rebuilt further upstream in 941 by the princes of Capua and was supported with a castle to resist the incursions of the Saracens and the Normans. The princes donated the church to the monks of Monte Cassino.
The Church of Sant’Andrea was later dedicated to St. Benedict. It is mentioned in the documents from the sixteenth century onwards until its decadence and utter ruin took place in the nineteenth century when the Benedictine title was passed to the Church of Santa Maria delle Grazie. At the latter church a hospital for pilgrims and wayfarers operated.
Due to its secluded location, it was not affected by the great historical events. Only during World War II didi t find itself on the Gustav Line, the German defensive front, and was almost completely destroyed.
Most recently Sant’Andrea del Garigliano suffered severe damage during the 1984 earthquake and the flood of 1991.