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In the Middle Ages it was customary to build hospitals for the sick with care centers for the poor and pilgrims. They were furnished places with beds where the sick could be laid while a part of the building was always devoted to prayer and furnished with an altar and sacred images.

In Guarcino the Brotherhood of the Holy Spirit enlarged a chapel dedicated to St. Benedict integrating neighboring houses and making  the door of this hospital known in the narrow alleys of the village.